Cell & Gene Therapies

2+ hour, 31+ min ago   (400+ words) A recent narrative review of 16 academic papers highlights the complex ethical responsibilities facing researcher-clinicians who conduct first-in-human cell and gene therapy trials involving minors. The study finds that while existing literature often addresses the tension between clinical care and research,…...

40+ min ago   (286+ words) To address these barriers, researchers have been testing in situ administration — direct delivery into specific brain regions — in addition to developing advanced carriers such as lipid nanoparticles and next-generation viral vectors coated with high-affinity peptides. Lipid nanoparticles, for example, were…...

5+ hour ago   (1081+ words) Immuna Therapeutics AG, based in Allschwil, Basel region, Switzerland, and NIMS University Rajasthan, Jaipur, today announced a US3millionpartnershiptodevelopanaffordable,locallydeliveredmodelforCAR-TcelltherapyinRajasthan.AnnouncedattheWorldHealthSummitinBerlin,thecollaborationaimstoestablishaRajasthanCentreofExcellenceforCAR-Tclinicaldelivery,researchandtraining.NIMSwouldcontributeUS2 million towards infrastructure, clinical operations and patient care, while Immuna would contribute US$1 million in technology, training and technical…...

1+ day, 9+ hour ago   (954+ words) Researchers at the University of Cincinnati College of Medicine have published the first proof-of-concept study showing the potential of an experimental gene therapy for hydrocephalus. The preclinical research from the lab of Agnes (Yu) Luo, PhD, was recently published in…...

6+ hour, 54+ min ago   (491+ words) A phase I trial at Ohio State found that CAR T cells engineered to target three B-cell proteins and boosted with OX40, manufactured in just six days and infused fresh, produced remissions with minimal side effects in patients with relapsed B-cell…...

2+ hour, 11+ min ago   (225+ words) UA.NEWS Rice University boosts Cas13a sensitivity for HIV detection 100-fold — News-Medical Researchers at Rice University have developed a modified version of the Cas13a enzyme for detecting RNA viruses. In a laboratory test using a synthetic, noninfectious HIV sample, the system’s sensitivity…...

10+ hour, 26+ min ago   (735+ words) Researchers at the University of Cincinnati College of Medicine have published the first proof-of-concept study showing the potential of an experimental gene therapy for hydrocephalus. The preclinical research from the lab of Agnes (Yu) Luo, PhD, was recently published in…...

9+ hour, 22+ min ago   (212+ words) In a phase I clinical trial, researchers at The Ohio State University Comprehensive Cancer Center tested an enhanced CAR-T therapy for patients with B-cell blood malignancies that had returned after treatment or did not respond to it. As News-Medical reports,…...

11+ hour, 51+ min ago   (219+ words) As ArsenalBio, TScan, and others abandon ex vivo programs for in vivo engineering, early clinical data and platform differences point to both the promise and the unresolved safety, manufacturing, and regulatory questions of generating CAR-T cells inside the body. After…...

2+ week, 1+ day ago   (497+ words) When your own cells become medicine For some patients, the future of medicine isn’t a pill. It’s their own cells. Two patients, one with sickle cell disease and one with a rare blood cancer, turned to The University of Kansas…...