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Discovery & Preclinical
Targets, assays, animal models, and early safety/tox studies before human trials.
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Gut Microbes Prime Regulatory B Cells That Shape Cancer Immunotherapy
3+ day, 4+ hour ago (618+ words) Checkpoint inhibitors have transformed the treatment of advanced cancers, yet only a minority of patients derive lasting benefit, and many develop immune-related adverse events that force treatment to stop. A review published in Cancer Immunology, Immunotherapy by Akshay J. Patel and…...
Gut bacterial compound worsens brain injury after stroke, study suggests
3+ day, 21+ hour ago (12+ words) Medical Xpress...
Gut bacterial metabolite worsens brain damage after stroke, study finds
4+ day, 56+ min ago (449+ words) News-Medical Be the first to rate this article Gut bacterial metabolite worsens brain damage after stroke, study finds Researchers at LMU have discovered how a metabolite produced by gut bacteria can influence brain damage after stroke. How much damage a…...
How Gut Bacteria Can Shape the Brain???s Response to Stroke
4+ day, 3+ hour ago (41+ words) How Gut Bacteria Can Shape the Brain’s Response to Stroke | Newswise Newswise How Gut Bacteria Can Shape the Brainâs Response to Stroke Researchers at LMU have discovered how a metabolite produced by gut bacteria can influence brain damage after…...
Availability of Two Draft Toxicological Profiles
4+ day, 14+ hour ago (160+ words) A Notice by the Agency for Toxic Substances and Disease Registry on 10/01/2026 This document has a comment period that ends in 90 days. (12/30/2026) View Comment Instructions Comments are limited to 5000 characters. The remaining character count is an approximation to help you…...
Wash. toxicology labs see progress on backlog, but evidence delays continue
1+ week, 2+ day ago (393+ words) State toxicology labs are dealing with an enormous backlog of alcohol and drug test evidence that could delay or jeopardize DUI prosecutions, officials warn. The Washington State Patrol reported that its toxicology division has experienced a 59% increase in forensic casework…...
Benzene Exposure Linked to Increased Allergic Rhinitis Risk
1+ week, 2+ day ago (392+ words) LONG-TERM exposure to benzene may be associated with an increased risk of allergic rhinitis and mortality among older adults, according to a large UK study. Researchers found that higher benzene exposure, a chemical commonly found in crude oil, gasoline, cigarette…...
Infographic: Chemical Safety Basics
1+ week, 3+ day ago (52+ words) EHSLeaders Infographic: Chemical Safety Basics Any chemical that can potentially cause harm is considered hazardous. Here are some tips to help workers make smart decisions about taking the necessary safety precautions around chemicals. For more information, see the Washington State…...
Washington state toxicology labs see progress on backlog, but evidence delays continue
1+ week, 3+ day ago (393+ words) State toxicology labs are dealing with an enormous backlog of alcohol and drug test evidence that could delay or jeopardize DUI prosecutions, officials warn. The Washington State Patrol reported that its toxicology division has experienced a 59% increase in forensic casework…...
ConsoneAI's DioScor predicts cross-species drug toxicity in 90 seconds accounting for sex and ethnicity
1+ week, 6+ day ago (1051+ words) The RSC Emerging Technologies finalist integrates machine learning across seven species and multiple organ systems — with early adopters estimating potential reductions in carcinogenicity preclinical costs from £4m to £900,000 A Yorkshire-based company has developed an AI platform that can predict drug toxicity…...